Venous thromboembolism (VTE) is a frequent and potentially fatal complication of immobility caused by cerebrovascular disease. This review examines the efficiency of deep vein thrombosis (DVT) prophylaxis methods. Patients with stroke initiated on DVT prophylaxis were compared with those who did not have any prophylaxis. Integrative review research design was used and included articles from 2010 to 2016. Search terms such as “DVT prophylaxis” and “stroke” were used to identify scientific publications. Of 173 studies identified, 12 articles were included and rated using the Canadian Medical Association and Center for Evidence-Based Medicine Level of Evidence ranking system. Of DVT prophylaxis methods identified, intermittent pneumatic compression device was superior to antiembolic stockings. Current data showed that the stockings were insufficient in preventing VTE. Heparin and low–molecular-weight heparin were efficient chemoprophylaxis in reducing the incidence of VTE. The combination of chemical and mechanical DVT prevention is recommended.