Anaplastic glioma after high-dose proton–photon radiation treatment for low-grade skull base chondrosarcoma

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We report the case of a 63-year-old man who developed an anaplastic oligoastrocytoma of the brain stem and midbrain 13 years after postoperative high-dose proton–photon radiation therapy for a recurrent low-grade chondrosarcoma of the skull base. To our knowledge, this is the first reported case of an anaplastic glioma after proton–photon irradiation.

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