E-009 Rescue Therapy with TPA is Associated with Higher Rate of ICH in the SWIFT Trial

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Abstract

Introduction

The main aim of this study is to investigate the mechanistic and clinical factors contributing to the beneficial effect of Solitaire over Merci in lowering symptomatic intracranial haemorrhage (SICH) in the SWIFT trial. We also sought to determine which radiographic ICH subtype affects clinical outcome.

Methods

The SWIFT trial database was analysed for incidence of different ICH subtypes in all 144 enrolled patients. Each ICH subtype was correlated with baseline clinical and imaging characteristics, procedural factors, and clinical outcome. Multivariate logistic regression model was used to identify the most significant predictors of the individual ICH subtypes.

Results

Table

Results

Among all analysed clinical and procedural factors for each ICH subtype, rescue therapy with TPA was the most common ICH predictor and occurred more frequently in the Merci group, although this difference was not statistically significant (10.9% vs 3.4%; p=0.085). Basal ganglia ICH was the only radiographic subtype associated with worsened outcome at 90 days (OR 3.33; p=0.025). SICH was associated with higher mortality (OR 5.73; p=0.048), mRS shift (OR 2.41; p=0.011), and high NIHSS (mean effect 22.35 points; p=0.004) at 90 days.

Disclosures

R. Raychev: None. R. Jahan: 2; C; Stryker Neurovascular. D. Liebesekind: 2; C; Stryker Neurovascular. J. Saver: 2; C; Stryker Neurovascular.

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