Spirituality and religiousness are associated with a lower risk of suicide. A detailed assessment of spirituality among 88 suicide attempters hospitalized after a suicide attempt was performed. Factors associated with the recurrence of suicide attempts over 18 months were looked into. Spirituality was low among most suicide attempters in comparison with the general population. Two groups were identified: those with a high score of depression who featured “low” in spirituality and those with a more heterogeneous profile, for example, involving personality disorders, characterized by a “high” spirituality. At the follow-up, the “meaning in life” score appeared to correlate with recurrence of suicide. Clinical implications are discussed herein.