PO031 Pregnancy outcomes in anti-nmda receptor encephalitis

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Abstract

Anti-N-methyl-d-aspartic (NMDA)-receptor encephalitis is an autoimmune condition characterised by a range of neuropsychiatric symptoms. When it manifests during pregnancy, placental transmission of IgG poses a theoretical risk to the foetus. We present a case of anti-NMDA-receptor encephalitis manifesting in a pregnant female patient, and the outcome of postnatal testing of the infant following the presenting pregnancy and subsequent pregnancy for anti-NMDA-receptor antibodies. Despite transmission of IgG as measured in infant serum, there was no cognitive or developmental impairment in the two infants reported in this case. This is likely due to a variety of maternal, placental and foetal factors that can influence illness severity in the offspring. Overall, maternal IgG can cross the placenta in anti-NMDA-receptor encephalitis. The transmission of these antibodies is not definitively associated with cognitive or developmental impairment of the infant.

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