PO083 Severity of impulsive compulsive behaviours in early parkinson’s disease

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Abstract

Objectives

Impulse control behaviours (ICBs) and impulse control disorders (ICDs) are a recognised side-effect of dopaminergic medication in Parkinson’s disease (PD). Some patients report mild ICB, while others exhibit severe symptoms requiring intervention. Previous studies have reported the prevalence of ICD diagnosis but the severity of ICBs in early Parkinson’s is not well known. In this cross-sectional study, we report the severity of ICBs in early PD.

Methods

We embedded a detailed cross-sectional study within the Oxford Discovery cohort. Participants (PD and healthy controls) identified as at risk of ICD using a screening questionnaire (QUIP-anytime-PD-short) underwent a semi-structured interview using the Parkinson’s impulse-control scale (PICs) to grade severity and intensity. ICDs were diagnosed using DSM 5.

Results

Out of 1380 participants enrolled into the Discovery cohort, 267 (19.4%, 95% CI 17.3, 21.4) were at risk of ICD following screening. 124 were interviewed. This included 92 patients with Parkinson’s, of which 38 (41.3%, 95% CI 5=31.1, 52.1%) were affected with ICB and 10 had a diagnosis of ICD (10.9%, 95% CI 6.0, 18.9%).

Conclusion

ICBs are common in early Parkinson’s and future studies should consider syndromal and subsyndromal symptoms. Future work will examine risk factors for ICBs in this cohort.

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