PO155 Comparison of cognitive functioning between matched samples of aqp-4 antibody positive and mog antibody nmo patients with healthy controls

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Abstract

Objective

To compare cognitive functioning in aquaporin-4 (AQP4) antibody positive and myelin oligodendrocyte glycoprotein (MOG) antibody positive neuromyelitis optica (NMO patients) matched by age, education and disease duration with matched healthy control (HC) participants.

Method

15 NMO AQP4+, 15 NMO MOG +and 15 HC participants were administered a battery of neuropsychological tests. Test results were combined to give a single composite measure for cognitive functioning.

Results

Participants did not significantly differ on age, education level or disease duration. A significant overall effect of group was found on the cognitive composite measure. Post hoc analysis revealed NMO AQP4 +patients scored significantly worse than HCs (Tukey HSD; p=0.05), with no significant difference between NMO MOG+and HCs. Analysis of cognitive subtests identified significant differences on executive functioning testing between the NMO AQP4 +patients and HCs (Tukey HSD; p=0.02) but not between NMO MOG+patients and HCs.

Conclusions

Initial data confirms previous findings of evidence for cognitive impairments in NMO patients compared to HCs and indicates that cognitive dysfunction may be greater in AQP4 +patients compared to MOG+ patients, whom did not substantially differ from HCs.

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