Replenishing trained doctors is a major challenge faced by Cambodia as it recovers from the Genocide under the Khmer Rouge regime. Without an outcome-based undergraduate curriculum or a postgraduate Neurology training programme, combined with solely didactic methods of teaching, there is a desperate need for improved Neurology education. Collaborating with the only government-run medical school in Cambodia (University of Health Sciences), we aimed to improve Neurology education in a sustainable way by: 1. Developing an outcome-based Neurology curriculum, 2. Introducing simulation-based teaching in Neurology clinical skills, and 3. Building sustainable resources and ‘Training the trainers’ (14 local Neurologists and postgraduates) in simulation and how to adapt to a student-centred learning approach. We designed and delivered: 1. A 3 week ‘Interactive Neurology course’ for 180 students in Years 4–6, 2. Simulation-based clinical skills training for 500 students in Years 3–6 (surveys and evaluation demonstrating significant improvement in skills and perception), and 3. Videos and ‘simulation checklists’ in English and Khmer (local language) for history taking and examination for multiple neurological scenarios These activities serve as a solid foundation for the introduction of ‘active learning’, and pave the way for the introduction of simulation-based practice of neurological clinical skills in Cambodia.