WED 162 Cognitive impairment in a greek ms patient cohort using bicams

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Abstract

Introduction

Cognitive impairment (CI) can present in 40%–70% of MS patients and in the early stages of the disease. The Brief International Cognitive assessment for MS (BICAMS) is a brief, practical and potentially universal battery for cognitive assessment in MS.

Aim

To correlate cognitive function with clinical parameters as disease type, EDSS, and disease duration

Methods

The cognitive function was measured with the validated to the Greek population BICAMS tool, which consists of the Symbol Digit Modalities Test (SDMT), the Greek Verbal Learning Test (GVLT) and the Brief Visuospatial Memory Test-Revised (BVMT-R).

Results

36% patients classified as impaired according to the BICAMS battery. Progressive types of disease had worst scores than the relapsing in the SDMT (MD=1.73; 95% CI: 0.46, 3.0; p=0.009), GVLT (MD=1.77; 95% CI: 0.82, 2.72; p=0.001) and BICAMS z-score (MD=1.39; 95% CI: 0.54, 2.24; p=0.002). The two groups were also different in EDSS (p<0.001). EDSS showed correlation with BICAMS test. Disease duration did not correlate with CI. Age was identified as a risk factor of CI.

Discussion

Early management of CI can lead to improvement in the patient’s quality of life. Progressing types of the disease might benefit from early cognitive assessment in the disease course.

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