Hospitals that expand or open new nursing units must provide training to staff providing patient care in the new space. Although expansion represents a significant investment and has substantial implications for patient care, there is little evidence to guide best practice. This article describes an approach to education, training, and orientation used by a large academic medical center in the United States, which included simulation. The results of a program evaluation are discussed, demonstrating the positive impact of this program on staff readiness and patient safety. Nursing professional development practitioners may be able to use similar programs in their own facilities.