Homicide is the third leading cause of injury death in the workplace. The death certificate-based National Traumatic Occupational Fatalities surveillance system and estimates of annual employment were used to calculate average annual rates of work-related homicide for detailed industries and occupations for the nation for 1980 to 1989. Workers in the taxicab industry had the highest rate of work-related homicide (26.9 per 100,000 workers). High rates were also identified for workers providing public and private security, and in a number of retail trade and service industries. For many high-risk industries, the risk was excessive for male workers only. Differences between rates for black and nonblack workers varied across industries and occupations. Immediate efforts to protect workers, and long-term efforts to describe and study work-related homicide thoroughly and to evaluate interventions are needed.