Comparative effectiveness of colony-stimulating factors in febrile neutropenia prophylaxis: how results are affected by research design

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Abstract

Aims:

To examine the impact of research design on results in two published comparative effectiveness studies.

Methods:

Guidelines for comparative effectiveness research have recommended incorporating disease process in study design. Based on the recommendations, we develop a checklist of considerations and apply the checklist in review of two published studies on comparative effectiveness of colony-stimulating factors. Both studies used similar administrative claims data, but different methods, which resulted in directionally different estimates.

Results:

Major design differences between the two studies include: whether the timing of intervention in disease process was identified and whether study cohort and outcome assessment period were defined based on this temporal relationship.

Conclusion:

Disease process and timing of intervention should be incorporated into the design of comparative effectiveness studies.

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