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Nanoparticle properties such as size, shape, deformability, and surface chemistry all play a role in nanomedicine drug delivery. While many studies address the behavior of particle systems in a biological setting, revealing how these properties work together presents unique challenges on the nanoscale. Particle replication in non-wetting templates (PRINT®) is one molding technique that allows for fabrication of “calibration quality” micro and nanoparticles with independent control over their physical parameters. As the only technology in the world capable of independently optimizing and robustly manufacturing GMP compliant precision particles of virtually any size, shape, and composition, the PRINT technology has the capability to engineer the future of healthcare.