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The drug instability, toxicity and the barrier to the target area necessitate a suitable drug delivery system with an external or internal control of the release. Spatio-temporal control using a surface functionalized nano-carrier seems to be the best alternative for guided drug delivery and release. This manuscript provides a broad spectrum about the drug carrier interface modification to cover the need for temporal drug delivery control under neglect side effects. On the other hand, recent advances related to the drug vehicle are highlighted, besides physical (Electric field, magnetic field, light) or mechanical (Ultrasound, mechanical strain), chemical (pH, redox gradient, enzyme) stimuli mediated DDS. Precisely, the paper focus on the NIR light as an effective external stimulus for remotely-triggered DDS. NIR responsive drug delivery systems are considered as novel drug modality that ensures an eco-friendly spatiotemporal control and an administrated meditation. This study also investigated the NIIR spectroscopy (NIRS) combined with partial least square (PLS) for quantitative analysis of a polyvinyl alcohol based prodrug (PVA-DOX) in order to reveal the high potential of NIRS for drug release monitoring and the extraction of concise calibration models.