Retrograde pyelonephritis and lumbar spondylitis as a result ofSalmonella typhiin a type 2 diabetes patient with neurogenic bladder

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Abstract

We present a case of a 62-year-old diabetic woman with acute pyelonephritis and spondylitis caused by Salmonella typhi. She was admitted to Tokyo Medical Dental University Hospital, Tokyo, Japan, because of unconsciousness and was diagnosed with sepsis by retrograde pyelonephritis as a result of Salmonella typhi. Antibiotics treatment was immediately started; however, she subsequently developed lumbar spondylitis, and long-term conservative treatment with antibiotics and a fixing device were required. This is the first report of a diabetic patient who developed retrograde urinary tract infection with Salmonella typhi, followed by sepsis and spondylitis. The infection could be a result of diabetic neuropathy, presenting neurogenic bladder and hydronephrosis. The patient was successfully treated with antibiotics and became asymptomatic with normal inflammatory marker levels, and no clinical sign of recurrence was observed in the kidney and spine at 4 months.

62-year-old diabetic woman developed a retrograde urinary tract infection with Salmonella typhi, followed by sepsis and spondylitis. The infection could be due to diabetic neuropathy, presenting neurogenic bladder and hydronephrosis.

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