Knowledge translation activities may be targeted toward all participants in healthcare practices, including patients, consumers, and policy makers. Hereby, use of social media, namely, social network Facebook, as a tool for knowledge translation, promotion of evidence-based medicine, and high-quality information on health is described. In March 2013, a Facebook page of the Croatian Cochrane Branch was created and its main contents are translated plain language summaries of the systematic reviews produced by The Cochrane Collaboration. Since the page was created, it has gained 1441 followers, mostly from Croatia and neighboring countries with similar language. Most of the page followers are women aged 25 to 44 and the most popular content is related to pregnancy, childbirth, and breastfeeding. Page followers are lay persons, health professionals, and journalists, who further disseminate the page content. In summary, social media enables multiple possibilities to engage with target audience and to disseminate the evidence-based medicine content.