Messenger RNA Expression and Genetic Polymorphisms of Cell Cycle Control Genes and Chromosomal Aberrations in Chinese Vinyl Chloride Monomer-Exposed Workers

    loading  Checking for direct PDF access through Ovid

Abstract

Objective:

To evaluate the expressions of p53, p21, and CCND1 in the peripheral blood lymphocytes of vinyl chloride monomer (VCM)–exposed workers and potential relationships with their exposures, polymorphisms, and chromosomal aberrations.

Methods:

The study was performed on 77 occupationally VCM-exposed workers and 43 unexposed controls. The quantities of mRNA expression of p53, p21, and CCND1 genes were detected by real-time polymerase chain reaction.

Results:

p53 mRNA expression of VCM-low- and high-exposure groups was significantly lower than that of nonexposed group (P < 0.001), but p21 mRNA expression of the two VCM-exposed groups was significantly higher than that of the nonexposed group (P < 0.001). This study did not find the relationship between chromosomal aberrations, genotypes, and the expression of p53, p21, and CCND1.

Conclusions:

Messenger RNA expressions of p53 and p21 are changed with VCM-exposure status.

Related Topics

    loading  Loading Related Articles