Messenger RNA Expression and Genetic Polymorphisms of Cell Cycle Control Genes and Chromosomal Aberrations in Chinese Vinyl Chloride Monomer-Exposed Workers

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To evaluate the expressions of p53, p21, and CCND1 in the peripheral blood lymphocytes of vinyl chloride monomer (VCM)–exposed workers and potential relationships with their exposures, polymorphisms, and chromosomal aberrations.


The study was performed on 77 occupationally VCM-exposed workers and 43 unexposed controls. The quantities of mRNA expression of p53, p21, and CCND1 genes were detected by real-time polymerase chain reaction.


p53 mRNA expression of VCM-low- and high-exposure groups was significantly lower than that of nonexposed group (P < 0.001), but p21 mRNA expression of the two VCM-exposed groups was significantly higher than that of the nonexposed group (P < 0.001). This study did not find the relationship between chromosomal aberrations, genotypes, and the expression of p53, p21, and CCND1.


Messenger RNA expressions of p53 and p21 are changed with VCM-exposure status.

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