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This study aimed to elucidate the association between active commuting to work (ACW) and work performance among male office workers.This cross-sectional study included 331 male office workers (age 44.0 ± 11.5 years), with ACW assessed on a self-reported questionnaire and then categorized into non-ACW (0 to 19 minutes) and ACW (≥20 minutes). Work performance [World Health Organization Health and Work Performance Questionnaire (HPQ)] was categorized as high (≥50) and low (<50). Multiple logistic regression models were used to examine the association between ACW and HPQ.We found that 42.2% respondents adopted ACW. After adjusting for demographic data, lifestyle factors, and depressive symptoms, ACW was significantly associated with high HPQ (odds ratio: 2.43; 95% confidence interval: 1.30 to 4.54).In male office workers, ACW was independently associated with higher work performance.