Oxidative stress and inflammatory markers in normal pregnancy and preeclampsia

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Abstract

Aim

Although previous investigators have demonstrated the presence of oxidative stress and inflammation in preeclampsia, none directly correlate both to preeclampsia.

Methods

We determined in 35 preeclamptic and 35 normotensive pregnant women plasma levels of thiobarbituric acid reactive species, protein carbonyl, tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6 and IL-10.

Results

Plasma thiobarbituric acid reactive species and protein carbonyls were higher in preeclamptic patients. TNF-α and IL-6 (but not IL-1β or IL-10) were higher in preeclamptic patients. We found significant correlation between plasma IL-6 and carbonyls, and these correlated to blood pressure.

Conclusions

We demonstrated that some oxidative and inflammatory mediators were altered in preeclampsia, and some correlated to blood pressure.

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