Neonatal hemochromatosis is a difficult disorder to cure, and it has a high rate of recurrence. High–dose immunoglobulin treatment is very effective as prenatal treatment for recurrent neonatal hemochromatosis. A 34–year–old pregnant Japanese woman underwent high–dose immunoglobulin treatment for recurrent neonatal hemochromatosis. High–dose non–specific intravenous immunoglobulin (1 g/kg bodyweight) was administered to the mother intravenously every week from 18 until 36 gestational weeks. A male infant was delivered at 37 weeks of gestation, and his condition was favorable, including hepatic function. The use of γ–globulin for neonatal hemochromatosis appears adequately validated by experience.