Adhering to the schedule, providing service to passengers, and driving safely are among the most important psychosocial demands of the bus driver's job. The ways bus drivers cope with these varying and conflicting demands are addressed in this article, which uses data from 4 interrelated studies. In a large-scale questionnaire study (Study 1), behavioral styles in coping with these psychosocial demands were identified. Next, in Studies 2 and 3, the relations of these styles with well-being and health status were examined. Study 4 addressed the coping process during work itself by examining the relations among objective workload indicators, perceived effort, and psychophysiological stress reactions during work.