Unexpected Dramatic Increase in CD4+ Cell Count in a Patient With AIDS After Enfuvirtide Treatment Despite Persistent Viremia and Resistance Mutations

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Abstract

An unexpected dramatic immune recovery was observed in a patient with full-blown AIDS receiving enfuvirtide-based antiretroviral therapy after multiple treatment failures. A complex interplay of viral and host factors, including the control of X4 viruses and proviral burden, may favor immune restoration with HIV neutralizing activity, despite persistent viremia. J. Med.

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