Episodic Detection of Human Papillomavirus Within a Longitudinal Cohort of Young Women

    loading  Checking for direct PDF access through Ovid

Abstract

Redetection of a type-specific human papillomavirus (HPV) infection may represent reinfection. However, a growing body of literature suggests that reactivation of HPV is common and that episodic detection of a HPV infection may represent reactivation of a persistent virus. A cohort of prospectively followed adolescent women (N = 150), ages 14–17, was observed on average 6.4 years. The authors describe the redetection of 37 HPV types and associated factors of redetection of high-risk (HR) and low-risk (LR) types using Cox proportional hazard models. Of 1,248 HPV type-specific infections, 286 (22.9%) were associated with redetection after apparent clearance. Chlamydia infections (HR = 1.99 [95%CI, 1.15–3.49]) and non-condom use (HR = 1.1 [95%CI, 1.04–1.99]) were associated with increased redetection of HR-HPV infections. Oral contraceptive pills (HR = 2.73 [95%CI, 1.52–4.90]) and number of sexual partners (HR = 1.44 [95%CI, 1.04–1.99]) were associated with increased redetection of LR-HPV infections. Episodic detection of HPV is common for HR- and LR-HPV types. This finding and identified factors or redetection have clinical implications and enhances the understanding of HPV natural history. J. Med. Virol. 87:2122–2129, 2015. © 2015 Wiley Periodicals, Inc.

Related Topics

    loading  Loading Related Articles