Effect of Systemic Intermittent Administration of Human Parathyroid Hormone (rhPTH[1–34]) on the Resistance to Reverse Torque in Rabbit Tibiae

    loading  Checking for direct PDF access through Ovid

Abstract

The aim of this study was to evaluate the effect of intermittent administration of human parathyroid hormone [rhPTH (1–34)] on the removal torque of implants placed in rabbit tibiae. Twenty male New Zealand rabbits were submitted to implant surgery. Each animal received one machined screw-type implant (3.75 mm diameter × 8 mm length) in the proximal metaphysis of the right tibia. The rabbits were then divided into 2 groups: the test group (n = 10) received 6 μg/kg of rhPTH (1–34) subcutaneously in the dorsal region 3 days a week, and the control group (n = 10) received placebo. Removal torque was performed at 28 and 56 days after implant placement for both groups. The mean removal torque values at 28 days were 37.0 ± 4.36 Ncm and 47.4 ± 6.77 Ncm for control and test groups respectively (P < .05). At 56 days the reverse torque was 45.8 ± 3.96 Ncm for the control group and 55.8 ± 2.86 Ncm for the test group, indicating that the removal torque was significantly higher in the test groups (P < .05). These results demonstrated that intermittent treatment with rhPTH (1–34) enhanced the removal torque of implants in rabbit tibiae.

Related Topics

    loading  Loading Related Articles