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The number of joint replacements is increasing annually. One of the most serious complications with total joint arthroplasties is infection. Periprosthetic joint infections (PJIs) are difficult to treat, have a high impact on patients’ lives, and are a serious economic burden. Prevention of PJIs is important. Use of laminar airflow (LAF) systems has been considered a possible preventive measure; however, from the perspective of the current literature, it is possible that this assumption should be reconsidered. This minireview provides an overview of important aspects within the representative literature about the use of LAF systems and why they should be reconsidered as standard technology in the operating room.