Inflammation is a complex physiologic response with various theoretical effects on the bone-healing process. Retrospective studies show conflicting results: some cases demonstrate that prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) leads to healing complications, while others negate this finding. Prospective studies have shown that NSAIDs offer quality pain control and possibly show no deleterious effects with early, short-term use. While some data are concerning regarding NSAID use during bone-healing, it is difficult to draw conclusions regarding predictive factors. Based on current studies, NSAIDs should be limited to short-term use.