In Vivo Effect of Photodynamic Therapy on Periodontal Bone Loss in Dental Furcations

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The purpose of this study was to histometrically evaluate the influence of photodynamic therapy on bone loss in furcation areas in rats with experimentally induced periodontal disease.


Ligatures were placed on the first mandibular molar in rats. Then the animals were divided into four groups: control group = no treatment; methylene blue group (MB) = treated topically with methylene blue (100μg/ml); laser group (LLLT) = treated with low-level laser therapy; and photodynamic therapy group (PDT) = treated topically with MB followed by LLLT (4.5 J/cm2). Rats from all groups were sacrificed at 7, 15, or 30 days postoperatively. The area of bone loss in the furcation region of the first molar was histometrically analyzed. Data were analyzed statistically (analysis of variance and Bonferroni tests; P<0.05).


The PDT group demonstrated less bone loss compared to the other groups at 7 days (1.986 ± 0.417 mm2); at 15 days, the PDT (1.641 ± 0.115 mm2) and MB groups (1.991 ± 0.294 mm2) demonstrated less bone loss compared to the control (4.062 ± 0.416 mm2) and LLLT (2.641 ± 0.849 mm2) groups.


Within the parameters used in this study, PDT may be an effective alternative for control of bone loss in furcation areas in periodontitis. J Periodontol 2008;79:1081–1088.

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