Verification of the effectiveness of the Fourier transform infrared spectroscopy computational model for colorectal cancer

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HighlightsPhysics-based computational model reflects the efficacy of chemotherapy.Post-chemotherapy colon tissues FTIR spectrum was similar with healthy one.FTIR is a sensitive distribution indicator for the main biochemical compounds of healthy and cancerous colon tissue.Cancerogenesis caused changes in spectrum representing the vibration of carbohydrate, protein and lipid functional groups.Colorectal cancer is one of the most common cancers. Its formation is influenced by genetic and environmental factors. Despite the continuous development of diagnostic tools and cancer therapies, there are no methods that allow a real-time estimation of treatment efficiency. This method can be a vibrational spectroscopy. The resulting infrared spectrum (FTIR) of the tissue gives us information about the chemical composition and the content of the individual components.We have noticed that tumor tissues, healthy and after chemotherapy tissues, have different vibrational spectra. It was also shown that spectra acquired from normal (benign) tissues were similar to those derived from tissues post-chemotherapy. The similarity was greater, when the effectiveness of chemotherapy, confirmed by medical documentation, was better. Therefore, we decided to use the physical model proposed in our earlier paper to verify its correctness and to show whether a particular type of chemotherapy was effective or not. Comparison of the results obtained from the physical model with patients data have been found as close to the physical condition.

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