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It is highly desirable to have a universal detector that can detect all types of compounds and give a uniform response regardless of the physiochemical properties of the compounds. With such a universal detector, all components in a sample can be accurately quantified without the need for individual standards. This is especially needed for the characterization of unknowns and for non-targeted analysis, or for samples that have no isolated standards available for each component. Over the years, much effort has been put into seeking a universal detection technology. In this review, we discuss the commonly used detectors for analytical characterization, including UV, RI, ELSD, CAD, CLND, FID, VUV, MS, NMR, and hyphenated detection, with the focuses on the “universal” features of these detectors regarding the types of molecules they can detect and the uniformity of responses.Universal detectors that can detect all types of compounds and give uniform response are highly desirable.Reviewed commonly used detectors in analytical characterization, with the focuses on the “universal” features.UV, RI, ELSD, CAD, CLND, FID, VUV, MS, NMR, etc. and hyphenated detections are reviewed.