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Delamination of veneering ceramic is reported as one of the most frequent problems associated with veneered zirconia restorations.The purpose of this in vitro study was to compare the shear bond strength of sintered lithium disilicate to that of pressed fluorapatite glass-ceramic on a zirconia substrate.Thirty zirconia blocks (20×15×2.5-mm thick) were cut, sintered, and divided into 2 groups. A pressed group, a zirconia liner, was applied and sintered, and the lost-wax technique was used to fabricate fluorapatite glass-ceramic blocks (3×3×3 mm), which were pressed onto the sintered zirconia blocks. A sintered group, lithium disilicate blocks, were cut (3×3×3 mm) and sintered to the sintered zirconia blocks by using a low-fusing glass-ceramic. The thickness of the low-fusing glass-ceramic was standardized to approximately 80 μm prior to sintering. The shear bond strength levels of the specimens were tested using a universal testing machine at a crosshead speed of 1 mm/min until failure. Representative separated specimen surfaces were examined for fracture characteristics, using scanning electron microscopy at ×50 magnification. Debonding data were compared using a 2-tailed, unpaired Studentttest (α=.05).The sintered group demonstrated mean shear bond strength values (41.2 ±6.3 MPa), which were significantly higher (P<.001) than those of the pressed group (21.3 ±4.3 MPa).Sintering of computer-aided design and computer-aided manufacturing (CAD-CAM) lithium disilicate ceramic achieved higher shear bond strength values than pressing fluorapatite glass-ceramic to zirconia substructure material.