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Implant prosthodontics provides high-quality outcomes thanks to recent technological developments and certification procedures such as International Organization for Standardization (ISO) 14801. However, these certification tests are costly, and the result is highly uncertain as the influence of design variables (materials and structure) is still unknown. The design process could be significantly improved if the influence of design parameters were identified.The purpose of this in vitro study was to use finite element analysis (FEA) to assess the influence of design parameters on the mechanical performance of an implant in regard to testing conditions of ISO 14801 standard.An endosseous dental implant was loaded under ISO 14801 testing conditions by numerical simulation, with 4 parameters evaluated under the following conditions: conditions of the contact surface area between the implant and the loading tool, length of the fixation screw, implant embedding depth, and material used for implant stiffness. FEA was used to compare the force that needed to reach the implant's yield and fracture strength.A dental implant's fracture point can be increased by 41% by improving the contact surface area, by 20% depending on the type of material, by 4% depending on the length of the fixation screw, and by 1.4% by changing the implant embedding depth.FEA made it possible to evaluate 4 performance parameters of a dental implant under ISO 14801 conditions. Under these conditions, the contact surface area was found to be the major parameter influencing implant performance. This observation was validated experimentally in a fatigue test under ISO 14801 conditions.