Successful treatment of a staphylococcal endocarditis vegetation with tissue plasminogen activator

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A 930 gm premature infant had Staphylococcal endocarditis with a tricuspid valvular vegetation that was unresponsive to antibiotics and not amenable to resection.Infusion of tissue plasminogen activator over a 3-day period completely lysed the vegetation. The infection cleared with continued antibiotics, and the infant recovered without sequelae. (J Pediatr 1998;132:535-7)

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