Assessment of the Efficacy of Interceed After Hysterectomy in Preventing Adhesion Formation in the Rabbit Model

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Abstract

Objective

The purpose of this study was to evaluate the effectiveness of oxidized regenerated cellulose in preventing adhesions after hysterectomy when placed over a peritoneal defect after the vaginal cuff was closed.

Methods

Thirty rabbits who underwent hysterectomy were randomized into one of three groups: (1) in 10 there was no reperitonealization, (2) in 10 pelvic peritonea were closed with a running stitch of 6–0 polyglycolic acid suture, and (3) in 10 oxidized regenerated cellulose was placed over the peritoneal defect. Two weeks after the initial operative procedure, the animals were killed. Adhesions were scored for tenacity and percent of defect covered by adhesions.

Results

Comparison of the three groups by analysis of variance revealed no statistical significance in either the tenacity of adhesions (p = 0.9508) or the extent of surface with adhesions (p = 0.1862). However, the lowest mean adhesion scores were noted in the spontaneously healed defect group, followed by the suture closure group, followed by the oxidized regenerated cellulose group.

Conclusions

These data suggest that, in the rabbit model, spontaneous closure of peritoneal defects after major pelvic surgery allows for better healing than suture reapproximation or antiadhesion barrier (oxidized regenerated cellulose) usage on these surfaces.

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