Self-assembling bis-dendritic peptides: design, synthesis and characterization of oxalyl-linked bis-glutamyl peptides[Glun(CO2Me)n + 1-CO-]2;n = 1,3,7

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Abstract

Three generations of glutamic acid dendrons[Glun(CO2Me)n + 1; n = 1, 3, 7] have been joined together head-to-head by an oxalyl unit to form highly sterically congested bis-Glu-dendritic peptides with gelling properties. The single crystal X-ray structure of the first generation bis-dendritic peptide showed an extended hydrogen-bonded chiral tape with modest nonlinear optical activity.

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