Retrospective diagnosis of hypoxic myocardial injury in premature newborns

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Abstract

Aim

To investigate usefulness of cardiac troponin (cTnT) and creatinine kinase MB (CK-MB) in the diagnosis of myocardial injury due to birth hypoxia and to correlate these markers with cardiac functions as measured by echocardiogram.

Methods

We studied 43 preterm infants: 21 with birth asphyxia and 22 controls. Echocardiographic studies and quantitative determination of cTnT and CK-MB in blood serum was performed between the 12th and the 24th h of life.

Results

cTnT and CK-MB levels were higher in asphyxiated infants compared to controls (0.287 ± 0.190 vs. 0.112 ± 0.099 ng/mL, P < 0.001) and (18.35 ± 14.81 vs. 11.09 ± 5.17 ng/L, P < 0.05). Among controls, we observed an elevated value of cTnT in those with respiratory distress syndrome (RDS). We found a decrease in fractional shortening (P < 0.05) and an increase in tricuspid insufficiency (P < 0.01) in asphyxiated newborns.

Conclusions

cTnT and CK-MB levels are strong indicators of myocardial injury due to perinatal hypoxia. The cTnT level was most strongly related to RDS.

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