Correlation between plasma and urinary caffeine levels in preterm infants

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Abstract

Background

We hypothesize that urine levels might be reliable to assess the therapeutic range of caffeine.

Objectives

We correlated plasma and urinary levels of caffeine in preterm infants treated with this drug for apnea of prematurity.

Methods

Infants (n=56) were given a loading dose of caffeine citrate (10 mg/kg, per os) and 24 h later a maintenance dose (2 mg/kg, per os, once a day). Plasma and urinary levels of caffeine were determined 24 h after the loading dose (before administration of the maintenance dose) and then weekly.

Results

Plasma and urinary levels correlate at all examined ages: 29 weeks (r = 0.92, P<0.001), 30 weeks (r = 0.97, P<0.001), 31 weeks (r = 0.82, P<0.001), 32 weeks (r = 0.92, P<0.001), 33 weeks (r = 0.87, P<0.001), 34 weeks (r = 0.81, P<0.001).

Conclusion

Urinary levels of caffeine might be a useful means to assess therapeutic ranges.

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