Donor Lymphocyte Infusions to Displace Residual Host Hematopoietic Cells after Allogeneic Bone Marrow Transplantation for β-Thalassemia Major

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Abstract

Purpose: Donor lymphocyte infusion (DLI) was used to reverse relapse after allogeneic bone marrow transplantation (BMT) in a patient with β-thalassemia major.

Patients and Methods: The patient with unstable mixed chimerism after BMT was treated with graded increments of donor lymphocytes (105 T cells/kg to 5×l07 T cells/kg) to displace residual hematopoietic host cells.

Results: DLI resulted in complete donor-derived reconstitution of the hematopoietic compartment. The patient developed mild graft-versus-host disease (GVHD) that could be controlled by steroid treatment.

Conclusions: This case report shows that DLI can effectively eradicate host stem cells in mixed chimeras after BMT in non-malignant hematopoietic diseases.

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