CD30-Positive Anaplastic Large Cell Lymphoma (ALCL) of T-Cell Lineage in a 14-Month-Old Infant With Perinatally Acquired HIV-1 Infection

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Abstract

Purpose: CD30-positive anaplastic large cell lymphoma (ALCL) has been described in adults with HFV-1 infection but is extremely rare in HIV-1 -infected infants and children.

Patient and Methods: A 14-month-old girl with congenitally acquired HIV-1 infection presented with fever and a tender, erythematous, cystic mass on the right labium majorum. The mass was biopsied. Histologic examination and immunohistochemistry were performed.

Results: Histologic examination showed Touton-like giant cells resembling histiocytes and focally abundant neutrophils obscuring the lymphoid infiltrate. Immunocytochemistry revealed a CD30-positive ALCL of T-cell lineage.

Conclusion: Although non-Hodgkin's lymphoma is known to be associated with HIV-1 infection in children, large cell lymphomas of T-cell lineage are extremely rare in this population. Early diagnosis should be aggressively pursued in an HIV-1-infected child who presents with a fever and cutaneous mass

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