Unusual Genetic Aberrations Including a Deletion of KLF6 Tumor Suppressor Gene Revealed by Integrated Cytogenetic Approaches in a Pediatric Ewing Sarcoma

    loading  Checking for direct PDF access through Ovid

Abstract

Ewing sarcoma is the third most common sarcoma in children and young adults. Its characteristic chromosomal rearrangement results in a chimerical EWSR1-ETS transcription factor. Secondary genetic alterations are very common. Membranous expression of CD99 is seen in almost all tumors. We report 2 unusual cytogenetic findings in a pediatric Ewing sarcoma, an insertion of the MIC2 gene encoding CD99 from Xp to 10p and a submicroscopic deletion of the well-known tumor supressor gene KLF6. The latter has not been described previously in pediatric neoplasms. Molecular pathways in tumorigenesis and genetic complexity in cancer are discussed.

Related Topics

    loading  Loading Related Articles