Clinical Burdens of β-Thalassemia Major in Affected Children

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Abstract

Background:

β-thalassemia major (BTM) is an inherited blood disorder leading to severe anemia. A better understanding of BTM complications can be considered an important factor in developing effective health care provision.

Method:

A descriptive exploratory design was used to identify the clinical burden of BTM from affected children's perspective. A convenience sample of 45 patients with BTM, accompanied by a family member, was recruited from a governmental hospital during April–May 2015.

Results:

The most reported clinical burden was facial deformity 86.9%, followed by systematic infection (48.8%), growth delay (44.4%), and liver problems (39.9%). Patient age was significantly associated with clinical burdens such as bone pain and facial deformity. The number of blood transfusions received was associated with growth delay and bone pain.

Conclusion:

This study highlights the clinical burdens of thalassemia on affected children, in terms of physical appearance, growth delay and other burdens.

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