Journal of Pediatric Hematology/Oncology. 40(4):e263–e265, MAY 2018
DOI: 10.1097/MPH.0000000000001053
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PMID: 29240029
Issn Print: 1077-4114
Publication Date: 2018/05/01
Thiamylal Plus Pentazocine Shows Similar Efficacy as Ketamine Plus Midazolam for Painful Procedures in Children With Leukemia
Shunsuke Nakagawa;Yasuhiro Okamoto;Yuichi Kodama;Takuro Nishikawa;Takayuki Tanabe;Yoshifumi Kawano;
+ Author Information
Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Abstract
This retrospective study compared the use of thiamylal plus pentazocine (TP) to ketamine plus midazolam (KM) in children with leukemia who were undergoing bone marrow aspiration and/or intrathecal chemotherapy. A total of 268 procedures in 35 children with leukemia were retrospectively analyzed for efficacy and adverse events. All procedures were successfully completed without severe adverse events. TP induced significantly faster sedation. The incidents of desaturation were significantly greater in the TP group, but were transient and recovered by oxygen supplementation alone. Therefore, TP can be a useful combination with a similar efficacy as KM for painful procedures in children.
