The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome

    loading  Checking for direct PDF access through Ovid


Fetal growth restriction (FGR) is a significant complication of pregnancy describing a fetus that does not grow to full potential due to pathological compromise. FGR affects 3–9% of pregnancies in high-income countries, and is a leading cause of perinatal mortality and morbidity. Placental insufficiency is the principal cause of FGR, resulting in chronic fetal hypoxia. This hypoxia induces a fetal adaptive response of cardiac output redistribution to favour vital organs, including the brain, and is in consequence called brain sparing. Despite this, it is now apparent that brain sparing does not ensure normal brain development in growth-restricted fetuses. In this review we have brought together available evidence from human and experimental animal studies to describe the complex changes in brain structure and function that occur as a consequence of FGR. In both humans and animals, neurodevelopmental outcomes are influenced by the timing of the onset of FGR, the severity of FGR, and gestational age at delivery. FGR is broadly associated with reduced total brain volume and altered cortical volume and structure, decreased total number of cells and myelination deficits. Brain connectivity is also impaired, evidenced by neuronal migration deficits, reduced dendritic processes, and less efficient networks with decreased long-range connections. Subsequent to these structural alterations, short- and long-term functional consequences have been described in school children who had FGR, most commonly including problems in motor skills, cognition, memory and neuropsychological dysfunctions.

The structural and functional deficits that are associated with fetal growth restriction in human infants are dependent on a number of important factors, including the timing of the onset of placental insufficiency and subsequent fetal hypoxia and hypoglycaemia, the severity of fetal compromise, whether the FGR infant is born preterm or at term, whether coexisting complications are present, and the cerebrovascular responses including whether brain sparing is evident and the severity of brain sparing, as well as the spatial redistribution of brain blood flow.

Related Topics

    loading  Loading Related Articles