Complexities of Personalized Medicine: How Genes, Drug-Drug Interactions, Dosing Schedules, and Other Factors Can Combine to Produce Clinically Meaningful Differences in a Drug’s Effect

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Abstract

Given increased knowledge from molecular biology and pharmacology, it is apparent that multiple factors can interact to produce clinically meaningful differences in a drug’s effect in specific individuals (i.e., personalized medicine). This topic is discussed in this column using iloperidone as an example. The variables discussed include dose, dosing schedule, genes, drug-drug interactions, and other medical factors. How such variables can combine to alter a drug’s effect is illustrated with a case example and the results of a thorough QTc study of iloperidone. (Journal of Psychiatric Practice 2013;19:397–405)

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