Five-year follow-up study of the association between periodontal disease and myocardial infarction among Japanese male workers: MY Health Up Study

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Abstract

Background

An association between chronic oral infections and coronary heart disease has been suggested.

Methods

The study participants were male employees aged 36–59 years. Data were extracted from the MY Health Up Study, comprising a baseline questionnaire survey and succeeding annual health examinations for financial firm workers in Japan. Using a self-administered questionnaire at baseline, participants' oral status was classified into three types of periodontal indicators: (i) periodontal score, (ii) periodontitis and (iii) tooth loss (<5 and ≥5 teeth). An incidence of myocardial infarction (MI) was determined by annual health examination records.

Results

Of the 4037 candidates for follow-up in the baseline year of 2004, 3081 males were eligible for the analysis, 17 of whom experienced MI in the subsequent 5 years. The periodontal score model was associated with an increase in developing MI [odds ratio (OR) = 2.11, 95% confidence interval (CI) = 1.29–3.44], after adjusting for other confounding variables. The periodontitis (OR = 2.26, 95% CI = 0.84–6.02) and tooth loss (OR = 1.97, 95% CI = 0.71–5.45) models showed similar trends, although the difference was not significant.

Conclusions

Periodontal disease may be a mild but independent risk factor for MI among Japanese male workers.

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