Keating, XD, Castelli, D, and Ayers, SF. Association of weekly strength exercise frequency and academic performance among students at a large university in the United States. J Strength Cond Res 27(7): 1988–1993, 2013—The study aimed to examine (a) the association between weekly strength exercise frequency and grade point average (GPA), and (b) the demographic characteristics of weekly strength exercise frequency among undergraduate students at a large southern state university in the United States. Health behavior data (N = 1125) collected by the American College Health Association at the university in 2008 were analyzed. Analysis of variance was used to investigate weekly strength exercise frequency differences in GPA, sex, ethnicity, and year in university. The results revealed that those who more frequently engaged in strength exercise had significantly higher GPA. There was a significant difference in weekly strength exercise frequency by sex and ethnicity. Findings suggest that regular engagement in strength exercise may not only have physical health benefits but is also associated with academic achievement in high education. There is a need to further investigate the mechanism of strength exercise on GPA among university students.