Side Effects of Pharmacotherapy on Bone with Long-Acting Gonadorelin Agonist Triptorelin for Paraphilia

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There have been limited research studies concerning the use of libido inhibitors for the treatment of patients with a paraphilia. Observational studies suggest that agents that lower testosterone are an effective treatment for paraphilia.


We report a case of hormonal treatment of paraphilia that was associated with side effects.


A 35-year-old man with a paraphilia was treated with long-acting gonadorelin.


The desired result was reduced preoccupation with sexuality, but there were various side effects including a serious amount of bone loss.


We believe that more attention should be given to the adverse effects of long-term treatment with triptorelin. In our view the drug regime needs to be revised.

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