Intraoperative assessment of margins in breast conservative surgery—still in use?

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A positive margin in breast conserving surgery is associated with an increased risk of local recurrence. Failure to achieve clear margins results in re-excision procedures. Methods for intraoperative assessment of margins have been developed, such as frozen section analysis, touch preparation cytology, near-infrared fluorescence optical imaging, x-ray diffraction technology, high-frequency ultrasound, micro-CT, and radiofrequency spectroscopy. In this article, options that might become the method of choice in the future are discussed. J. Surg. Oncol. 2014 110:15–20. © 2014 Wiley Periodicals, Inc.

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