Clinical face transplantation, only 10 years old, has evolved into a safe and preferred reconstructive option for the most severe facial defects, in which traditional reconstructive methods have yielded poor outcomes. The ability to simultaneously restore facial function and aesthetics has shown to improve patient's quality of life. Its applicability to post-oncologic resection, however, remains guarded given the current international experience with respect to long term outcomes. J. Surg. Oncol. 2016;113:971–975. © 2016 Wiley Periodicals, Inc.