aDepartment of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, ChinacDepartment of Interventional Therapy, Fudan University Shanghai Cancer Center, Shanghai, ChinadDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, ChinabDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
Checking for direct PDF access through Ovid
Objective:To investigate whether lymph node ratio and log odds ratio can be used for predicting the prognosis of patients with lung adenocarcinoma.Methods:A total of 1097 patients with lung adenocarcinoma who underwent complete surgical resection and systematic lymph node dissection between 2008 and 2013 were studied retrospectively. Lymph node ratio was calculated as: Symbol. Log odds ratio was calculated as: Symbol. Patients were grouped respectively into 4 groups by the use of recursive partitioning according to their lymph node ratio and log odds ratio. Linear trend χ2 test was used for measuring monotonicity and discriminatory power.Results:The 3-year survival rate was 91.0% (89.9%-92.1%) for group 0, 75.2% (71.4%-79.0%) for group 1, 56.5% (51.5%-61.5%) for group 2, and 41.4% (36.4%-46.4%) for group 3 of lymph node ratio, respectively. In addition, the 3-year survival rate was 89.9% (88.7%-91.1%) for group 1, 78.4% (74.4%-82.4%) for group 2, 56.0% (50.9%-61.1%) for group 3, and 41.0% (36.1%-45.9%) for group 4 of log odds ratio, respectively. Univariable and multivariable Cox models identified that both lymph node ratio and log odds ratio were significant prognostic factors for patients' survival. Log-rank test of trend χ2 statistics of both lymph node ratio (P < .001) and log odds ratio (P < .001) showed significant differences.Conclusions:Both lymph node ratio and log odds ratio can be used as prognostic factors for clinicians to predict patients' prognosis.