Polymorphisms of the Serotonin Transporter Gene and Their Relation to Premature Ejaculation in Individuals from Iran

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Abstract

Purpose:

This study tested whether individuals with at least 1 copy of the short (S) or long (L)G allele of the serotonin transporter gene-linked polymorphic region exhibit a greater incidence of premature ejaculation compared with LALA individuals.

Materials and Methods:

The serotonin transporter gene-linked polymorphic region was genotyped in 82 men with lifelong premature ejaculation and 82 age matched healthy controls. With respect to the serotonin transporter gene-linked polymorphic region we analyzed the data under the 3 models of 1) dominant S model (S/S + S/LA + S/LG + LG/LG + LA/LG vs LA/LA), 2) dominant L model (LA/LA + LA/LG + S/LA vs S/S + S/LG + LG/LG) and 3) genotype model (S/S + LG/LG + S/LG vs S/LA + LA/LG vs LA/LA).

Results:

The prevalence of the serotonin transporter gene-linked polymorphic region S/S genotype in patients with premature ejaculation was significantly higher than in the control group (p = 0.001). A significantly higher S allele frequency of the serotonin transporter gene-linked polymorphic region was noted in patients with premature ejaculation compared with that in controls (p = 0.001). In the patients with premature ejaculation the S allele frequency was 70.7% compared with 57.3% in the control group (p = 0.001). Individuals with at least 1 copy of the S allele at the serotonin transporter gene-linked polymorphic region experienced more premature ejaculation compared to those who were LA homozygotes (p = 0.001). The prevalence of the dominant S model and genotype model in patients with premature ejaculation was higher than in normal subjects (78% vs 65%, p = 0.02 and 51% vs 27%, p = 0.01). However, the differences were not statistically significant after applying the Bonferroni correction.

Conclusions:

Our findings indicate that men who carry the serotonin transporter gene-linked polymorphic region S/S, LG/LG or S/LG genotype have increased odds of premature ejaculation. Further investigation in this interesting field is necessary.

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